Cost per mille requires only that the publisher make the advertising available on his or her website and display it to the page visitors in order to receive a commission. Pay per click requires one additional step in the conversion process to generate revenue for the publisher: A visitor must not only be made aware of the advertisement but must also click on the advertisement to visit the advertiser's website.
There’s no limits to the number of affiliate programs you sign up for so applying for one today will not prevent you from picking another one later on.  In fact, being a member of more affiliate programs simply gives you more options in terms of products to promote plus they’re pretty much all free to join.  You can always leave a program if it’s not working out for you or there are no products you want to promote.
(e)You will not (and you will not seek to) purchase, register or otherwise use any Amazon Mark (as defined in the Trademark Guidelines) or variations or misspellings of any of those words (e.g., “ammazon,” “amaozn,” and “kindel,”) for use in any Search Engine . In addition to any other rights or remedies available to us, upon our request you will cause any Search Engine designated by us to exclude Proprietary Terms (defined below) from keywords used to display your advertising content in association with search results (e.g., request exclusion by negative keyword bidding), assuming the Search Engine offers such exclusion capabilities.
For sites looking to monetize their existing traffic through affiliate marketing, a major determinant of success is picking the right offers to run. The difference in earnings from a bad offer and a good one can be enormous. Unfortunately, finding the “right” offer isn’t exactly easy; if you’re using an affiliate marketing network such as Commission Junction (now part of Conversant), SharesASale, or LinkShare, you will have literally thousands of affiliate offers available to you.
Building trust with your audience is paramount in affiliate marketing, and the quickest way to lose trust is to recommend products either you haven’t used before or that aren’t a good fit for your audience. Also make sure you never tell anyone to directly buy a product, you are simply recommending the product. The more helpful you are and the more you make quality recommendations, the more likely your web visitors will come back for your expertise. 
Some advertisers offer multi-tier programs that distribute commission into a hierarchical referral network of sign-ups and sub-partners. In practical terms, publisher "A" signs up to the program with an advertiser and gets rewarded for the agreed activity conducted by a referred visitor. If publisher "A" attracts publishers "B" and "C" to sign up for the same program using his sign-up code, all future activities performed by publishers "B" and "C" will result in additional commission (at a lower rate) for publisher "A".
It’s also important to research their payout structure. Not all payouts are the same and tier affiliate marketing often offer different payouts. Some might pay you on the first offer but pay you nothing on any upsells. Ideally, you should be paid for every transaction. In doing your research, you’ll find out which affiliate payout structures are the most profitable.
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